There are no long-term side effects from taking plan B often (infertility) but short-term can include bloating, nausea, feeling unwell and other hormonal side effects which can definitely affect your quality of life. The makers of morning-after pills recommend only taking the pill once per cycle, but OBGYNs say that you can take the pill any time you have unprotected sex. If you find that you are taking the pill quite often because of unprotected sex, you might want to consider using condoms or talking to your doctor about other birth control alternatives.